Powerful Antioxidant Combination: Synergy of Vitamin C Neutral Form and Bioflavonoids

Vitamin C (ascorbic acid) is an essential vitamin known for its powerful antioxidant properties and its vital role in the immune system. However, in some people, the acidic nature of ascorbic acid can cause stomach upset. Developed to remedy this situation calcium ascorbatevitamin C, vitamin C neutral (buffered) and is characterized by its digestive system-friendly nature. The benefits of calcium ascorbate are usually found naturally in citrus fruits and works synergistically with vitamin C. bioflavonoids in combination with vitamin C. This powerful combination not only increases the absorption of vitamin C, but also shows positive effects on the overall cardiovascular system by supporting vascular health.

This comprehensive content details the role of calcium ascorbate as a source of vitamin C and the absorption-enhancing and vascular health-promoting effects of citrus bioflavonoids, based on scientific sources. It also includes the definition, biochemical composition, effects on the body (especially immune system, inflammation, cardiovascular health, physical performance and reproductive health), uses, side effects, dosage information and storage conditions for both ingredients.

Calcium Ascorbate Neutral Form of Vitamin C

Definition and Biochemical Composition

Calcium ascorbateis a form of vitamin C obtained by combining ascorbic acid (vitamin C) with calcium, a mineral, in salt form. This chelated or salted form, unlike traditional ascorbic acid non-acidic (pH neutral)This minimizes digestive discomfort in people with sensitive stomachs.

Biochemical Composition: Kalsiyum askorbat, C vitamini (yaklaşık %82) ve kalsiyum (yaklaşık %18) içerir. Vücutta hem C vitamini hem de kalsiyumun emilmesine ve kullanılmasına olanak tanır. Kalsiyum, kemik sağlığı, kas fonksiyonu ve sinir iletimi için önemli bir mineraldir.

Its Role as Vitamin C: Vitamin C from calcium ascorbate is a powerful vitamin that protects cells from oxidative damage by neutralizing free radicals in the body is an antioxidant. It is also vital for the function of cells of the immune system. It acts as a coenzyme in many biochemical processes such as collagen synthesis, iron absorption, neurotransmitter production and protein metabolism.

Citrus Bioflavonoids: Synergists to Improve Absorption and Support Vascular Health

Definition and Biochemical Composition

Citrus bioflavonoidsare a group of phytochemicals found abundantly in the peels, pulp and white interior of citrus fruits (oranges, lemons, grapefruits, etc.). They are often referred to as "Vitamin P", but they are not a true vitamin. They include various compounds such as rutin, hesperidin, quercetin, naringin and diosmin.

Biochemical Composition: Bioflavonoids belong to the class of phenolic compounds and have antioxidant, anti-inflammatory and antiallergic properties.

Vitamin C Absorption Enhancing Effect: The most well-known synergistic effect of bioflavonoids is that they increase the absorption and utilization of vitamin C by the body. Although the mechanism for this is not fully understood, bioflavonoids are thought to protect vitamin C from oxidation, keeping it active longer or facilitating its cellular uptake. This is particularly important in increasing the effectiveness of vitamin C supplements.

 

Effects on Body Functions (in Combination)

The combination of calcium ascorbate and citrus bioflavonoids offers more comprehensive and powerful benefits compared to vitamin C intake alone.

1. Powerful Antioxidant Support: Both vitamin C and bioflavonoids are powerful antioxidants. Together, their ability to neutralize free radicals is increased, which protects cells from oxidative stress and damage. Oxidative stress plays an important role in the aging process and the development of many chronic diseases (cardiovascular diseases, cancer, neurodegenerative diseases).
   • Research Example: A study by Cao et al. (1998) showed that the antioxidant activity of vitamin C may increase when taken together with bioflavonoids and that this combination may provide better protection against oxidative damage.
2. Cardiovascular Health and Vascular Function: The effects of this combination on cardiovascular health are significant:
   • Supporting Vascular Integrity and Flexibility: Vitamin C is essential for the synthesis of collagen (a protein found in the structure of blood vessels). Bioflavonoids help to strengthen capillaries and reduce their permeability, which can prevent bruising and bleeding.
   • Reducing Inflammation: Both vitamin C and bioflavonoids may lower the risk of atherosclerosis (hardening of the arteries) by reducing inflammation in the vessel wall.
   • Antioxidant Protection: Protects vascular cells from oxidative damage.
   • Blood Pressure Regulation: Some studies have shown that both vitamin C and bioflavonoids can help lower blood pressure.
   • Research Example: A meta-analysis by Peterson et al. (2020) reported that flavonoid intake may reduce the risk of cardiovascular disease and improve endothelial function. Vitamin C is also known to show the potential to lower blood pressure and improve endothelial function (Juraschek et al., 2020).
3. Immune System Support:
   • Vitamin C: It is critical for the production and function of immune cells. It increases the activity of phagocytes such as macrophages and neutrophils, promotes the development of T and B lymphocytes and increases antibody production. It can reduce the duration and severity of colds.
   • Bioflavonoids: They can have antiviral and antibacterial properties and work together with vitamin C to boost the immune response.
   • Impact Together: This synergistic combination supports the overall health of the immune system by increasing the body's resistance to infections.
4. Reducing Inflammation: Both vitamin C and bioflavonoids have anti-inflammatory properties. They can help reduce chronic inflammation by modulating inflammatory responses in the body. This can contribute to alleviating the symptoms of inflammatory conditions such as allergies, arthritis.
5. Skin Health and Collagen Synthesis:
   • Vitamin C: Indispensable for the synthesis of collagen (the protein responsible for the elasticity and firmness of the skin). It accelerates the healing of wounds, reduces skin pigmentation and protects against UV damage.
   • Bioflavonoids: Working together with vitamin C, it can help prevent collagen breakdown and protect skin cells from oxidative stress.
   • Impact Together: This combination provides essential support for healthy, youthful-looking skin, accelerates wound healing and protects the skin against environmental damage.
6. Iron Absorption: Vitamin C significantly increases the absorption of plant-derived iron (non-heme iron). Especially for vegetarians and vegans, this combination may be beneficial in reducing the risk of iron deficiency anemia.
7. Physical Performance: Thanks to their antioxidant properties, they can help reduce oxidative stress and muscle damage after exercise, which speeds up recovery and indirectly supports physical performance. Vitamin C also contributes to reducing fatigue.
8. Reproductive Health: Its antioxidant properties may contribute to reproductive health by protecting sperm and egg cells from oxidative damage. Vitamin C also plays a role in maintaining hormonal balance.

Areas of Use

The combination of calcium ascorbate and bioflavonoids is a popular supplement used for various purposes:

• General Immune Support: During cold and flu seasons or when the immune system is weakened.
• Antioxidant Protection: In individuals exposed to environmental toxins or under high oxidative stress.
• Cardiovascular Health: Those who want to protect or promote cardiovascular health.
• Skin Health and Collagen Support: To improve skin elasticity, accelerate wound healing and reduce signs of aging.
• Iron Absorption: In individuals with or at risk of iron deficiency anemia, especially in combination with iron supplements.
• Acidic Vitamin C Sensitivity: People with gastric sensitivity to vitamin C in the form of ascorbic acid.

Side Effects and Dosage Information

The combination of calcium ascorbate and bioflavonoids is generally considered safe at recommended doses.

Side Effects:

• Calcium Ascorbate Less likely to cause stomach upset than acidic forms of vitamin C. Diarrhea or mild gastrointestinal discomfort may occur rarely at high doses.
• Bioflavonoids: They are usually well tolerated. Rarely, mild side effects such as stomach upset, diarrhea or headache may occur.
• Drug Interactions: 
  • Vitamin C: At high doses it may interact with some blood thinners (e.g. warfarin).
  • Bioflavonoids: Some flavonoids (especially quercetin) may affect drug metabolism via cytochrome P450 enzymes. Therefore, it is important for people taking regular medication to consult their doctor before taking supplements.

Dosage Information:

Dosages in these combination supplements vary according to the formulation and intended use of the product.

• Vitamin C (as Calcium Ascorbate): 
  • Recommended Daily Allowance (RDA): Adult Men: 90 mg/day; Adult Women: 75 mg/day.
  • Tolerable Upper Intake Limit (UL): 2000 mg/day.
  • In supplements, it is usually 500 mg to 1000 mg calcium ascorbate (400-800 mg as elemental vitamin C).
• Citrus Bioflavonoids: 
  • There is no definitive RDA or UL.
  • In supplements, it is usually 100 mg to 500 mg include citrus bioflavonoids. They are usually formulated with vitamin C in a 1:1 or 2:1 ratio (vitamin C:bioflavonoids).

It is imperative to consult a health professional (doctor, dietitian, pharmacist) before using any supplements, especially if there is an existing health condition or medications being used.

Storage Conditions

Proper storage conditions are important to maintain the quality and shelf life of calcium ascorbate and bioflavonoid supplements:

• Cool and Dry Environment: It should be stored in a cool (usually room temperature) and dry place away from moisture and excessive heat.
• Far from the Light: It should not be exposed to direct sunlight, because vitamin C and some bioflavonoids are sensitive to light and can be degraded.
• Airtight Containers: To minimize contact with oxygen and preserve the freshness of the product, it should be stored in its original tightly closed packaging.
• Manufacturer's Instructions: The storage instructions on the packaging must be observed.

Sources

• Cao, G., Booth, S. L., Sadowski, J. A., & Prior, R. L. (1998). Increases in dietary antioxidant capacity after consumption of citrus bioflavonoids. Free Radical Biology and Medicine, 25(8), 929-938.
• Juraschek, S. P., Miller, E. R., & Gelber, A. C. (2020). Effect of vitamin C supplementation on blood pressure: A systematic review and meta-analysis of randomized controlled trials. American Journal of Clinical Nutrition, 111(6), 1184-1193.
• National Institutes of Health (NIH) Office of Dietary Supplements. (Current Information).
• Peterson, J. J., Dwyer, J. T., Bhagwat, S., & Haytowitz, D. B. (2020). Dietary flavonoid intake and all-cause and cause-specific mortality: a prospective cohort study. American Journal of Clinical Nutrition, 112(1), 162-171.
• USDA National Nutrient Database for Standard Reference. (Current Release).