How Apilarnil Changes Your Body

Apilarnil is not only a bee product; it is a rich source of biological content that carries the life energy of the human body cell by cell. It offers comprehensive effects including cellular regeneration, immune protection, hormone regulation and heart health support.

Description of Apilarnil:

Apilarnil, bal arılarının 3-7 günlük erkek larvalarından elde edilen, zengin besin içeriğine sahip doğal bir arı ürünüdür. Arı larvalarının özel işlemlerle toplanıp homojenize edilmesiyle elde edilen bu madde, vitaminler, mineraller, amino asitler, hormonlar ve antioksidan bileşikler açısından oldukça zengindir. İçeriğindeki yüksek protein oranı (%25-30 civarında), B grubu vitaminleri (özellikle B1, B2, B3, B5, B6 ve B12), A, D ve E vitaminleri ile kalsiyum, magnezyum, potasyum gibi mineraller sayesinde sağlık açısından önemli faydalar sağlar.

Health Effects of Apilarnil

The positive effects of apilarnil on the immune system have been scientifically researched. Apilarnil extracts have been shown to support immune functions by increasing the production of immune cells. It is also stated that the antioxidant content of apilarnil plays an important role in strengthening the immune system.

Anti-inflammatory and Antioxidant Effects:
Research on the anti-inflammatory properties of apilarnil has revealed that it may be a potential support in the treatment of chronic inflammatory diseases by reducing inflammation. Especially in experiments performed in endotoxemia (LPS-induced) models, apilarnil significantly reduced inflammation in cardiac tissue and suppressed the expression of proinflammatory cytokines such as TNF-α. These findings suggest that the antioxidant and anti-inflammatory properties of apilarnil are effective in preventing organ damage.

Cardioprotective Effects:
The preventive properties of apilarnil against LPS-induced cardiac injury were investigated. As a result of the study, it was observed that apilarnil significantly reduced edema, hemorrhage and inflammatory infiltration in heart tissue. It was also found to suppress the increase of heart damage markers such as BNP (brain natriuretic peptide).

Energy Boost and Physical Performance:
The high protein content of apilarnil supports energy metabolism and improves physical performance. Increased energy levels have been reported in athletes consuming Apilarnil.

Blood Sugar and Cholesterol Control:
The use of high doses of apilarnil has been observed to lower blood sugar and cholesterol levels in animal experiments. In a study conducted in broiler chickens, it was found that the group given high doses of apilarnil had lower blood sugar and cholesterol levels than the control group.

Effects on Reproductive Health:
Apilarnil is known to have positive effects on reproductive functions. For example, in a study conducted in pigs, it was reported to increase the fertility rate. It is also suggested that it may be beneficial in humans by supporting hormonal balance in conditions such as sexual dysfunction in men and PMS symptoms in women.

Uses of Apilarnil

Apilarnil is used to prevent or relieve the following health problems

• Strengthening the immune system
• Supportive treatment of chronic inflammatory diseases
• Protecting heart health
• Boosting energy levels
• Providing blood sugar and cholesterol control
• Supporting reproductive health (fertility problems, hormonal imbalances)
• Skin regeneration and anti-aging effects

Things to Consider When Using Apilarniline

Although apilarnil is generally recognized as safe, some important points should be considered during its use:

Allergic Reactions:
Apilarnil may contain small amounts of pollen, propolis and honey. Therefore, there is a risk of allergic reaction in people allergic to bee products. Although rare, cases of anaphylactic reaction have been reported in the literature.

Side Effects and Dosage Control:
Gastrointestinal symptoms such as stomach pain, nausea, vomiting and diarrhea may occur in overdose. In addition, signs of toxicity may be seen at high doses; it may lead to hormonal imbalances such as hyperandrogenism (excessive secretion of androgen hormones) or hyperspermatogenesis (excessive increase in sperm production).

Storage Conditions:
Apilarniline activity is sensitive to temperature. Therefore, it should be kept in the cold chain or stored in lyophilized form. Otherwise it may deteriorate rapidly.

Scientific Statistics on the Use of Apilarnil

• Apilarnil has been observed to increase the activity of immune cells.
• In a study conducted in animals, it was found to increase the fertility rate.
• Increased energy levels have been reported in athletes.
• Administration of a strong dose of apilarnil on animals significantly lowered blood glucose and cholesterol levels.
• It significantly reduced tissue damage by suppressing the production of harmful chemical messengers (TNF-α) in heart damage caused by bacterial toxins in the body.

Bibliography:

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2. Abd El-Wahed AA, Khalifa SAM, Aldahmash B, Zhang H, Du M, Zhao C, Tahir HE, Saeed A, Hussain H, Guo Z, El-Seedi HR. Exploring the Chemical Constituents and Nutritive Potential of Bee Drone (Apilarnil): Emphasis on Antioxidant Properties. Chem Biodivers. 2024 May;21(5):e202400085. doi: 10.1002/cbdv.202400085. Epub 2024 Apr 18. PMID: 38329156.
3. Elashal MH, Abd El-Wahed AA, Mohamed MA, Hamad R, Abd Eldaim MA, Khalifa SAM, Aldahmash B, El-Seedi HR, El-Aarag B. Apilarnil ameliorates Bisphenol A-induced testicular toxicity in adult male rats via improving antioxidant potency and PCNA expression. Reprod Toxicol. 2024 Apr;125:108570. doi: 10.1016/j.reprotox.2024.108570. Epub 2024 Mar 12. PMID: 38484946.
4. Doganyigit Z, Okan A, Kaymak E, Pandır D, Silici S. Investigation of protective effects of apilarnil against lipopolysaccharide induced liver injury in rats via TLR 4/ HMGB-1/ NF-κB pathway. Biomed Pharmacother. 2020 May;125:109967. doi: 10.1016/j.biopha.2020.109967. Epub 2020 Feb 2. PMID: 32018220.
5. Inandiklioglu N, Doganyigit Z, Okan A, Kaymak E, Silici S. Nephroprotective effect of apilarnil in lipopolysaccharide-induced sepsis through TLR4/NF-κB signaling pathway. Life Sci. 2021 Nov 1;284:119875. doi: 10.1016/j.lfs.2021.119875. Epub 2021 Aug 10. PMID: 34384831.