How Bromelain Changes Your Body

Bromelain is a cornerstone of biological balance by regulating many mechanisms in the body. Thanks to its enzymatic structure, Bromelain not only breaks down proteins and regulates body fluids, but also has a field of action that simultaneously affects many biological processes from inflammation to immune response and cellular repair.

Bromelain Definition

Bromelain is an enzyme complex derived from the fruit, root and/or stem of the pineapple plant and has been studied for its various health effects. Bromelain supplements have shown many pharmacological properties such as anti-inflammatory, edema-reducing, anticoagulant and anti-cancer activities.

Bromelain's anti-inflammatory properties are particularly noteworthy, and its anti-cancer effects are attributed to its ability to stimulate the self-destruction mechanism of tumorizing cells, inhibit the ability to form new vessels, and boost the immune response. Furthermore, Bromelain has shown potential to improve glucose metabolism and reduce insulin resistance, suggesting possible benefits for diabetics.

Health Effects of Bromelain

Bromelain supplements are used for various purposes, these are listed below:

• Protein Degradation: It facilitates digestion by breaking down proteins.
• Gas and bloating: Relieves gas, bloating and stomach ailments.
• Inflammation Reduction: Relieves joint disorders, sports injuries and muscle pain.
• Arthritis It can reduce pain and swelling in people with arthritis.
• Empowerment: It reduces inflammation levels in the body, allowing the immune system to function better.
• Respiratory Tract Infections: It may have an expectorant effect.
• Swelling and Bruising: It can be useful in reducing swelling, bruising and pain.
• Fast Recovery: It can help patients recover faster after surgical operations.
• Blood Circulation It can reduce the risk of thrombosis (blockage of blood vessels) by improving blood circulation.
• Blood Thinner It should be used with caution as it has a blood thinning effect.
• Sinusitis Symptoms: It can relieve symptoms of nasal congestion and sinusitis.
• Skin Regeneration: Can be used as a skin regenerator in cosmetic products

Things to Consider When Taking Bromelain Supplements

It is important to take some precautions when using this supplement:

• Bleeding Risk:
  Bromelain may affect the blood's ability to clot and therefore may increase the risk of bleeding in people taking blood thinners (for example, warfarin or aspirin). It is therefore recommended to stop using Bromelain two weeks before surgery.
• Allergic Reactions:
  Bromelain may cause allergic reactions in people who are allergic to pineapple. If you are allergic to fruits such as pineapple or papaya, you should avoid using bromelain.
• Drug Interactions:
  Bromelain may interact with some medicines. Caution should be exercised especially when used with blood thinners and some blood pressure medications.
• Kidney Disease:
  Supplements containing bromelain should be used with caution in people with kidney disease.
• Side Effects:
  Although bromelain is generally considered safe, in some people it may cause side effects such as upset stomach, diarrhea or skin rashes. If you experience such side effects, stop use and consult a health professional.
• Dosage
  When using bromelain supplements, it is important not to exceed the recommended dosage. Prefer to use it according to the recommendation of a health professional. If this is not possible, be sure to follow the warnings on the product you are taking.

Taking these precautions into account, you can use bromelain supplements safely. If you have any questions or concerns, you should consult your doctor.

Health Statistics Related to Bromelain

The health effects of bromelain supplements have been studied in several clinical trials, summaries of this information are listed below:

• Postoperative Recovery:
  In a study conducted after mandibular third molar surgery, it was shown that pain, swelling and jaw locking decreased in patients receiving bromelain and pineapple extract, and the need for painkillers decreased.
• Osteoarthritis (joint calcification):
  In a descriptive study in patients with osteoarthritis, a combination of bromelain and another plant extract was found to improve quality of life and reduce pain.
• General Health and Well-being:
  In a study in healthy adults, bromelain was shown to reduce knee pain and improve overall well-being.
• Anti-Cancer and Anti-Diabetic Effects:
  The anti-cancer and anti-diabetic properties of bromelain have been linked to mechanisms such as stimulation of the spontaneous death mechanism of tumoral cells, decreased ability to form new blood vessels and enhanced immune response.
• Side Effects and Safety: Bromelain is generally considered safe and no serious side effects have been reported even with long-term use.

Bibliography:

1. Colletti A, Procchio C, Pisano M, Martelli A, Pellizzato M, Cravotto G. An Evaluation of the Effects of Pineapple-Extract and Bromelain-Based Treatment after Mandibular Third Molar Surgery: A Randomized Three-Arm Clinical Study. Nutrients. 2024 Mar 9;16(6):784. doi: 10.3390/nu16060784. PMID: 38542694; PMCID: PMC10974198.
2. Kumar V, Mangla B, Javed S, Ahsan W, Kumar P, Garg V, Dureja H. Bromelain: a review of its mechanisms, pharmacological effects and potential applications. Food Funct. 2023 Sep 19;14(18):8101-8128. doi: 10.1039/d3fo01060k. PMID: 37650738.
3. Varilla C, Marcone M, Paiva L, Baptista J. Bromelain, a Group of Pineapple Proteolytic Complex Enzymes (Ananas comosus) and Their Possible Therapeutic and Clinical Effects. A Summary. Foods. 2021 Sep 23;10(10):2249. doi: 10.3390/foods10102249. PMID: 34681298; PMCID: PMC8534447.
4. Müller S, März R, Schmolz M, Drewelow B, Eschmann K, Meiser P. Placebo-controlled randomized clinical trial on the immunomodulating activities of low- and high-dose bromelain after oral administration - new evidence on the antiinflammatory mode of action of bromelain. Phytother Res. 2013 Feb;27(2):199-204. doi: 10.1002/ptr.4678. epub 2012 Apr 20. PMID: 22517542.
5. Consorti G, Monarchi G, Paglianiti M, Betti E, Balercia P. Reduction of Post-Surgical Facial Edema Following Bromelain and Coumarin Intake in Traumatology: A Prospective Study with 100 Patients. J Clin Med. 2024 Feb 6;13(4):922. doi: 10.3390/jcm13040922. PMID: 38398236; PMCID: PMC10889715.
6. Walker AF, Bundy R, Hicks SM, Middleton RW. Bromelain reduces mild acute knee pain and improves well-being in a dose-dependent fashion in an open study of otherwise healthy adults. Phytomedicine. 2002 Dec;9(8):681-6. doi: 10.1078/094471102321621269. PMID: 12587686.
7. Italiano G, Raimondo M, Giannetti G, Gargiulo A. Benefits of a Food Supplement Containing Boswellia serrata and Bromelain for Improving the Quality of Life in Patients with Osteoarthritis: A Pilot Study. J Altern Complement Med. 2020 Feb;26(2):123-129. doi: 10.1089/acm.2019.0258. Epub 2019 Nov 1. PMID: 31674795.