How Does Barbering Change Your Body?

Certain biological compounds rebuild the body's internal balance by influencing multiple regulatory systems simultaneously. Berberine is characterized by its comprehensive range of action, from regulation of blood sugar and energy metabolism to inflammation management, cell regeneration and support of gut health. This comprehensive functional action is an important support in the management of metabolic disorders.

Definition of Barber

Berberine supplementation refers to the use of berberine, an isoquinoline alkaloid derived from various plants, as a dietary supplement. Berberine is known for its anti-inflammatory, antioxidant and antimicrobial effects, especially for improving glucose and lipid metabolism. It is therefore used as a potential treatment in the management of metabolic disorders such as diabetes, cholesterol imbalance, obesity and heart-related diseases.

Berberine regulates glucose and lipid metabolism by activating the metabolic pathway referred to by the acronym AMPK, which may be useful in the management of Type 2 diabetes. Furthermore, berberine is thought to enhance its metabolic effects by modulating the gut microbiota.

Health Effects of Berberine Supplementation

Berberine is an alkaloid derived from various plants and has a wide range of pharmacological effects. Berberine supplementation is particularly used in the management of cardiometabolic diseases such as metabolic syndrome, type 2 diabetes, high cholesterol and high blood pressure.

Metabolic Effects:

• Berberine regulates glucose and lipid metabolism by activating the AMPK pathway, which is beneficial in the management of Type 2 diabetes.
• It reduces insulin resistance, stimulates the breakdown of sugar and inhibits sugar production.

• In the treatment of high cholesterol, it increases good cholesterol (HDL) levels while lowering bad cholesterol (LDL) and triglyceride levels.

Anti-inflammatory and Antioxidant Effects:

Berberine has anti-inflammatory and antioxidant properties, which can be beneficial in various conditions such as heart diseases and brain diseases.

Anticancer Effects:

It is emphasized that berberine can inhibit the growth of cancer cells, trigger cancer cell death and stop the cell cycle.

Things to Consider When Taking Berberine Supplements

There are some important points to consider when taking Berberine supplements:

• Bioavailability and Metabolism: Berberine has a very low bioavailability (less than 1 percent) and is metabolized in the liver. Therefore, the efficacy of berberine supplements can vary widely depending on characteristics such as production technology and formulation. In such cases, it is more important to use such supplements under the advice of a healthcare professional.
• Drug Interactions: Berberine may have a suppressive effect on various isoforms of the cytochrome enzyme family, especially on 2 cytochrome enzyme isoforms. This may lead to significant drug interactions when berberine is used with other drugs. For example, concomitant use of berberine with metformin, cyclosporine A or digoxin may increase plasma levels of these drugs and increase the risk of side effects.
• Side Effects: The most common side effects of berberine use are gastrointestinal symptoms, for example constipation and diarrhea. Furthermore, berberine may cause neurotoxicity at high doses and impair mitochondrial function.
• Cardiotoxicity: Berberine may increase the risk of cardiotoxicity when used together with medicines such as macrolide antibiotics or statins. These combinations may increase the risk of problems with the heart, such as arrhythmia.
• Dosage The safety of long-term use at high doses has not been fully established. Not exceeding the prescribed doses should be considered a sensible precaution for this new generation supplement.
• Special Cases: The use of berberine in patients who genetically lack the enzyme called glucose-6-phosphate dehydrogenase may increase the risk of jaundice. Also, berberine should be used with caution in patients with neurodegenerative disease, as it tends to accumulate in the central nervous system.

As a result, drug interactions, side effects and dosage should be considered when taking berberine supplements. Potential interactions and side effects should be considered, especially when used in combination with other medications.

Health Statistics on Berberine Supplements

Here are some important statistics on the use of barbering:

• Type 2 Diabetes:
  A systematic review of 46 studies on the effects of berberine showed that this herbal compound was able to lower fasting glucose by 0.86 mmol/L, HbA1c by 0.73% and 2-hour postprandial glucose by 1.26 mmol/L.
• Insulin Resistance:
  Berberine reduces fasting insulin levels by 2.05 mU/L and HOMA-IR levels by 0.71.
• Cholesterol Imbalance:
  Berberine decreases LDL cholesterol by 0.46 mmol/L, total cholesterol by 0.48 mmol/L and triglycerides by 0.34 mmol/L. It increases HDL cholesterol by 0.06 mmol/L.
• Safety Profile:
  Berberine is generally well tolerated and serious side effects are rare. The most commonly reported side effects are gastrointestinal symptoms, especially constipation and diarrhea.

Bibliography:

1. Li Z, Wang Y, Xu Q, Ma J, Li X, Li X, Yan J, Tian Y, Wen Y, Chen T. Berberine and health outcomes: An umbrella review. Phytother Res. 2023 May;37(5):2051-2066. doi: 10.1002/ptr.7806. Epub 2023 Mar 31. PMID: 36999891.
2. Ju J, Li J, Lin Q, Xu H. Efficacy and safety of berberine for dyslipidaemias: A systematic review and meta-analysis of randomized clinical trials. Phytomedicine. 2018 Nov 15;50:25-34. doi: 10.1016/j.phymed.2018.09.212. Epub 2018 Sep 28. PMID: 30466986.
3. Blais JE, Huang X, Zhao JV. Overall and Sex-Specific Effect of Berberine for the Treatment of Dyslipidemia in Adults: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials. Drugs. 2023 Apr;83(5):403-427. doi: 10.1007/s40265-023-01841-4. Epub 2023 Mar 21. PMID: 36941490.
4. Guo J, Chen H, Zhang X, Lou W, Zhang P, Qiu Y, Zhang C, Wang Y, Liu WJ. The Effect of Berberine on Metabolic Profiles in Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Oxid Med Cell Longev. 2021 Dec 15;2021:2074610. doi: 10.1155/2021/2074610. PMID: 34956436; PMCID: PMC8696197.
5. Zhao JV, Huang X, Zhang J, Chan YH, Tse HF, Blais JE. Overall and Sex-Specific Effect of Berberine on Glycemic and Insulin-Related Traits: a Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Nutr. 2023 Oct;153(10):2939-2950. doi: 10.1016/j.tjnut.2023.08.016. Epub 2023 Aug 19. PMID: 37598753.
6. Gasmi A, Asghar F, Zafar S, Oliinyk P, Khavrona O, Lysiuk R, Peana M, Piscopo S, Antonyak H, Pen JJ, Lozynska I, Noor S, Lenchyk L, Muhammad A, Vladimirova I, Dub N, Antoniv O, Tsal O, Upyr T, Bjørklund G. Berberine: Pharmacological Features in Health, Disease and Aging. Curr Med Chem. 2024;31(10):1214-1234. doi: 10.2174/0929867330666230207112539. PMID: 36748808.
7. Habtemariam S. Berberine pharmacology and the gut microbiota: A hidden therapeutic link. Pharmacol Res. 2020 May;155:104722. doi: 10.1016/j.phrs.2020.104722. Epub 2020 Feb 24. PMID: 32105754.
8. Caliceti C, Franco P, Spinozzi S, Roda A, Cicero AF. Berberine: New Insights from Pharmacological Aspects to Clinical Evidences in the Management of Metabolic Disorders. Curr Med Chem. 2016;23(14):1460-76. doi: 10.2174/0929867323666160411143314. PMID: 27063256.
9. Behl T, Singh S, Sharma N, Zahoor I, Albarrati A, Albratty M, Meraya AM, Najmi A, Bungau S. Expatiating the Pharmacological and Nanotechnological Aspects of the Alkaloidal Drug Berberine: Current and Future Trends. Molecules. 2022 Jun 9;27(12):3705. doi: 10.3390/molecules27123705. PMID: 35744831; PMCID: PMC9229